| ZFIN ID: ZDB-EXP-230505-1 |
Experiment Conditions Description: chemical treatment by environment: tolvaptan
| chemical treatment by environment: tolvaptan |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | tolvaptan |
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| Synonyms: | jinarc, N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide, OPC 41061, OPC-41061, samsca, tolvaptan |
| Definition: | A benzazepine derivative incorporating a benzenedicarboxamide function whch is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. Tolvaptan is a racemate consisting of a 1:1 mixture of 5R and 5S stereomers. |
| Ontology: | ChEBI [CHEBI:32246] ( EBI ) |
| Publication: | Oliveira et al., 2021 |
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