| ZFIN ID: ZDB-EXP-220629-2 |
Experiment Conditions Description: chemical treatment by injection: gonadotropin releasing hormone agonist, chemical treatment by injection: domperidone
| chemical treatment by injection: gonadotropin releasing hormone agonist |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | gonadotropin releasing hormone agonist |
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| Synonyms: | GnRH agonist, GnRH agonists, GnRH-A, gonadotrophin releasing hormone agonist, gonadotrophin releasing hormone agonists, gonadotropin releasing hormone agonists |
| Definition: | Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response. |
| Ontology: | ChEBI [CHEBI:63533] ( EBI ) |
| chemical treatment by injection: domperidone |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | domperidone |
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| Synonyms: | 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one, 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone, 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one, domperidona, domperidone, domperidonum |
| Definition: | 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. |
| Ontology: | ChEBI [CHEBI:31515] ( EBI ) |
| Publication: | Baker et al., 2019 |
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