| ZFIN ID: ZDB-EXP-190508-4 |
Experiment Conditions Description: chemical treatment by environment: okadaic acid, chemical treatment by environment: EC 2.7.11.26 (tau-protein kinase) inhibitor
| chemical treatment by environment: okadaic acid |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | okadaic acid |
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| Synonyms: | (2R)-2-hydroxy-3-{(2S,5R,6R,8S)-5-hydroxy-8-[(2R,3E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-e, 9,10-Deepithio-9,10-didehydroacanthifolicin, Okadaic acid |
| Definition: | A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. |
| Ontology: | ChEBI [CHEBI:44658] ( EBI ) |
| chemical treatment by environment: EC 2.7.11.26 (tau-protein kinase) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 2.7.11.26 (tau-protein kinase) inhibitor |
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| Synonyms: | [tau-protein] kinase inhibitor, [tau-protein] kinase inhibitors, ATP:[tau-protein] O-phosphotransferase inhibitor, ATP:[tau-protein] O-phosphotransferase inhibitors, ATP:tau-protein O-phosphotransferase inhibitor, ATP:tau-protein O-phosphotransferase inhibitors, brain protein kinase PK40erk inhibitor, brain protein kinase PK40erk inhibitors, cdk5/p20 inhibitor, cdk5/p20 inhibitors, CDK5/p23 inhibitor, CDK5/p23 inhibitors, EC 2.7.11.26 (tau-protein kinase) inhibitors, EC 2.7.11.26 inhibitor, EC 2.7.11.26 inhibitors, glycogen synthase kinase-3beta inhibitor, glycogen synthase kinase-3beta inhibitors, GSK inhibitor, GSK inhibitors, GSK-3 inhibitor, GSK-3 inhibitors, protein tau kinase inhibitor, protein tau kinase inhibitors, STK31 inhibitor, STK31 inhibitors, tau kinase inhibitor, tau kinase inhibitors, tau-protein kinase I inhibitor, tau-protein kinase I inhibitors, tau-protein kinase II inhibitor, tau-protein kinase II inhibitors, tau-tubulin inhibitor, tau-tubulin inhibitors, TPK I inhibitor, TPK I inhibitors, TPK II inhibitor, TPK II inhibitors, TPK inhibitor, TPK inhibitors, TTK inhibitor, TTK inhibitors |
| Definition: | An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26). |
| Ontology: | ChEBI [CHEBI:91092] ( EBI ) |
| Publication: | Koehler et al., 2018 |
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