ZFIN ID: ZDB-EXP-170315-1
Experiment Conditions Description: chemical treatment: PD158780
chemical treatment: PD158780
Name: chemical treatment
Synonyms:
Definition: Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000111]
Name: PD158780
Synonyms: 4-(3-bromoanilino)-6-(methylamino)pyrido[3,4-d]pyrimidine, 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine, 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine, N(4)-(3-bromophenyl)-N(6)-methylpyrido[3,4-d]pyrimidine-4,6-diamine, PD 158780, PD-158780
Definition: A pyridopyrimidine that is pyrido[3,4-d]pyrimidine-4,6-diamine in which the amino groups at positions 4 and 6 are substituted by a m-bromophenyl group and a methyl group, respectively. It is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity [IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4)]. It does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
Ontology: ChEBI [CHEBI:92843]  ( EBI )
Publication: Malmquist et al., 2013