| ZFIN ID: ZDB-EXP-170106-8 |
Experiment Conditions Description: chemical treatment by environment: formestane, chemical treatment by environment: 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
| chemical treatment by environment: formestane |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | formestane |
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| Synonyms: | 4-hydroxy-4-androstene-3,17-dione, 4-hydroxy-Delta(4)-androstenedione, 4-hydroxyandrost-4-ene-3,17-dione, 4-hydroxyandrostenedione, 4-OH-A, 4-OHAD, CGP 32349, CGP-32349, formestane, formestano, formestanum, Lentaron |
| Definition: | A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes. |
| Ontology: | ChEBI [CHEBI:75172] ( EBI ) |
| chemical treatment by environment: 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane |
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| Synonyms: | 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane, 2,2'-(hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate, diethylenetriamine NONOate, NOC-18 |
| Definition: | A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group. |
| Ontology: | ChEBI [CHEBI:50154] ( EBI ) |
| Publication: | Sykes et al., 2016 |
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