| ZFIN ID: ZDB-EXP-170106-5 |
Experiment Conditions Description: chemical treatment by environment: formestane, chemical treatment by environment: estrogen
| chemical treatment by environment: formestane |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | formestane |
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| Synonyms: | 4-hydroxy-4-androstene-3,17-dione, 4-hydroxy-Delta(4)-androstenedione, 4-hydroxyandrost-4-ene-3,17-dione, 4-hydroxyandrostenedione, 4-OH-A, 4-OHAD, CGP 32349, CGP-32349, formestane, formestano, formestanum, Lentaron |
| Definition: | A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes. |
| Ontology: | ChEBI [CHEBI:75172] ( EBI ) |
| chemical treatment by environment: estrogen |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | estrogen |
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| Synonyms: | estrogene, estrogenes, estrogenes Hormon, estrogeno, estrogenos, estrogens, oestrogen, Oestrogene, oestrogenes, oestrogens |
| Definition: | A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens. |
| Ontology: | ChEBI [CHEBI:50114] ( EBI ) |
| Publication: | Sykes et al., 2016 |
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