ZFIN ID: ZDB-EXP-170106-3
Experiment Conditions Description: chemical treatment by environment: formestane
chemical treatment by environment: formestane
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: formestane
Synonyms: 4-hydroxy-4-androstene-3,17-dione, 4-hydroxy-Delta(4)-androstenedione, 4-hydroxyandrost-4-ene-3,17-dione, 4-hydroxyandrostenedione, 4-OH-A, 4-OHAD, CGP 32349, CGP-32349, formestane, formestano, formestanum, Lentaron
Definition: A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
Ontology: ChEBI [CHEBI:75172]  ( EBI )
Publication: Sykes et al., 2016