| ZFIN ID: ZDB-EXP-161219-5 |
Experiment Conditions Description: cancer xenotransplantation, chemical treatment: selumetinib
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment: selumetinib |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | selumetinib |
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| Synonyms: | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, ARRY 142886, ARRY-142886, ARRY142886, AZD 6244, AZD-6244, AZD6244, selumetinib, selumetinibum |
| Definition: | A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor. |
| Ontology: | ChEBI [CHEBI:90227] ( EBI ) |
| Publication: | Modzelewska et al., 2016 |
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