| ZFIN ID: ZDB-EXP-261009-12 |
Experiment Conditions Description: primary cell culture: cerebrospinal fluid contacting neuron, chemical treatment by environment: isobutyraldehyde
| primary cell culture: cerebrospinal fluid contacting neuron |
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| Name: | primary cell culture |
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| Synonyms: | |
| Definition: | In vitro culture condition in which an embryo or adult fish is dissociated to a single cell suspension. The analysis is made on this cell culture. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000145] |
| Name: | cerebrospinal fluid contacting neuron |
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| Synonyms: | CSF-cN, CSF-cNs |
| Definition: | Spinal cord interneuron located along the central canal that extends a microvilliated apical process into the cerebrospinal fluid and extends ascending axonal projections ventrally and ipsilaterally. CSF-cNs are GABAergic neurons that express PKD2L1 (TRPP3) channels and have been shown to be chemosensory and mechanosensory, responding to pH and osmolarity changes as well as mechanical stimuli associated with tail bending. CSF-cNs originate from two distinct progenitor domains, p3 and pMN. CSF-cNs project onto caudal primary (CaP motor neurons) and commissural primary ascending (CoPA) sensory interneurons within the escape circuit as well as onto V0-v interneurons within the slow swimming circuit. |
| Ontology: | Anatomy Ontology [ZFA:0007120] |
| chemical treatment by environment: isobutyraldehyde |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | isobutyraldehyde |
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| Synonyms: | 2-methylpropanal, 2-methylpropionaldehyde, alpha-methylpropionaldehyde, isobutanal, isobutylaldehyde, isobutyric aldehyde |
| Definition: | A member of the class of propanals that is propanal substituted by a methyl group at position 2. |
| Ontology: | ChEBI [CHEBI:48943] ( EBI ) |
| Publication: | Prendergast et al., 2023 |
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