| ZFIN ID: ZDB-EXP-250815-5 |
Experiment Conditions Description: chemical treatment by environment: EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor, chemical treatment by environment: metronidazole
| chemical treatment by environment: EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor |
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| Synonyms: | [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitor, [histone H3]-dimethyl-L-lysine(4)FAD-dependent demethylase 1A inhibitors, amine oxidase (flavin containing) domain 2 inhibitor, amine oxidase (flavin containing) domain 2 inhibitors, AOF2 inhibitor, AOF2 inhibitors, BHC110 inhibitor, BHC110 inhibitors, CPRF inhibitor, CPRF inhibitors, EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitors, EC 1.14.99.66 inhibitor, EC 1.14.99.66 inhibitors, KDM1A inhibitor, KDM1A inhibitors, KIAA0601 inhibitor, KIAA0601 inhibitors, LSD1 inhibitor, LSD1 inhibitors, lysine (K)-specific demethylase 1A inhibitor, lysine (K)-specific demethylase 1A inhibitors, lysine demethylase 1A inhibitor, lysine demethylase 1A inhibitors, lysine-specific demethylase 1A inhibitor, lysine-specific demethylase 1A inhibitors, lysine-specific histone demethylase 1A inhibitor, lysine-specific histone demethylase 1A inhibitors |
| Definition: | An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66). |
| Ontology: | ChEBI [CHEBI:131509] ( EBI ) |
| chemical treatment by environment: metronidazole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | metronidazole |
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| Synonyms: | 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum |
| Definition: | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
| Ontology: | ChEBI [CHEBI:6909] ( EBI ) |
| Publication: | Ko et al., 2018 |
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