| ZFIN ID: ZDB-EXP-250815-4 |
Experiment Conditions Description: chemical treatment by environment: EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, chemical treatment by environment: entinostat, chemical treatment by environment: metronidazole
| chemical treatment by environment: EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
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| Synonyms: | ATP:cyclin phosphotransferase inhibitor, ATP:cyclin phosphotransferase inhibitors, Bur1 Cdk inhibitor, Bur1 Cdk inhibitors, Bur1 inhibitor, Bur1 inhibitors, Cak1 inhibitor, Cak1 inhibitors, Cak1p inhibitor, Cak1p inhibitors, cdc2 inhibitor, cdc2 inhibitors, cdc2 kinase inhibitor, cdc2 kinase inhibitors, Cdc28p inhibitor, Cdc28p inhibitors, CDK inhibitor, CDK inhibitors, cdk-activating kinase inhibitor, cdk-activating kinase inhibitors, Cdk-activating protein kinase inhibitors, Cdk1 inhibitor, Cdk1 inhibitors, Cdk19 inhibitor, Cdk19 inhibitors, Cdk2 inhibitor, Cdk2 inhibitors, Cdk3 inhibitor, Cdk3 inhibitors, Cdk4 inhibitor, Cdk4 inhibitors, Cdk5 inhibitor, Cdk5 inhibitors, Cdk6 inhibitor, Cdk6 inhibitors, Cdk7 inhibitor, Cdk7 inhibitors, Cdk8 inhibitor, Cdk8 inhibitors, Cdk9 inhibitor, Cdk9 inhibitors, cyclin A-activated cdc2 inhibitor, cyclin A-activated cdc2 inhibitors, cyclin A-activated cdk2 inhibitor, cyclin A-activated cdk2 inhibitors, cyclin D-cdk6 kinase inhibitor, cyclin D-cdk6 kinase inhibitors, cyclin D-dependent kinase inhibitor, cyclin D-dependent kinase inhibitors, cyclin E kinase inhibitor, cyclin E kinase inhibitors, cyclin-A associated kinase inhibitor, cyclin-A associated kinase inhibitors, cyclin-dependent kinase 6 inhibitor, cyclin-dependent kinase 6 inhibitors, cyclin-dependent kinase inhibitor, cyclin-dependent kinase inhibitors, cyclin-dependent kinase-2 inhibitor, cyclin-dependent kinase-2 inhibitors, cyclin-dependent kinase-4 inhibitor, cyclin-dependent kinase-4 inhibitors, cyclin-dependent protein kinase activating kinase inhibitor, cyclin-dependent protein kinase activating kinase inhibitors, cyk inhibitor, cyk inhibitors, D-type cyclin kinase inhibitor, D-type cyclin kinase inhibitors, EC 2.7.11.22 (cyclin-dependent kinase) inhibitors, EC 2.7.11.22 inhibitor, EC 2.7.11.22 inhibitors, ndk inhibitor, ndk inhibitors, neuronal cdc2-like kinase inhibitor, neuronal cdc2-like kinase inhibitors, PCTAIRE-1 inhibitor, PCTAIRE-1 inhibitors, STK25 inhibitor, STK25 inhibitors |
| Definition: | An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22). |
| Ontology: | ChEBI [CHEBI:82665] ( EBI ) |
| chemical treatment by environment: entinostat |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | entinostat |
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| Synonyms: | BAY 86-5274, BAY86-5274, entinostat, entinostatum, MS 27-275, MS 275, MS-27-275, MS-275, N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide, N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester, pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate, SNDX 275, SNDX-275 |
| Definition: | A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3). |
| Ontology: | ChEBI [CHEBI:132082] ( EBI ) |
| chemical treatment by environment: metronidazole |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | metronidazole |
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| Synonyms: | 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum |
| Definition: | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
| Ontology: | ChEBI [CHEBI:6909] ( EBI ) |
| Publication: | Ko et al., 2018 |
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