| ZFIN ID: ZDB-EXP-200925-8 |
Experiment Conditions Description: cancer xenotransplantation, chemical treatment by environment: EC 3.5.1.98 (histone deacetylase) inhibitor, chemical treatment by environment: crizotinib
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment by environment: EC 3.5.1.98 (histone deacetylase) inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | EC 3.5.1.98 (histone deacetylase) inhibitor |
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| Synonyms: | EC 3.5.1.98 (histone deacetylase) inhibitors, EC 3.5.1.98 inhibitor, EC 3.5.1.98 inhibitors, HDAC inhibitor, HDAC inhibitors, HDACi, HDACis, HDI, HDIs, histone amidohydrolase inhibitor, histone amidohydrolase inhibitors, histone deacetylase (EC 3.5.1.98) inhibitor, histone deacetylase (EC 3.5.1.98) inhibitors, histone deacetylase inhibitor, histone deacetylase inhibitors |
| Definition: | An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). |
| Ontology: | ChEBI [CHEBI:61115] ( EBI ) |
| chemical treatment by environment: crizotinib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | crizotinib |
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| Synonyms: | (R)-crizotinib, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine, crizotinib, crizotinibum, PF 2341066, PF-2341066 |
| Definition: | A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) |
| Ontology: | ChEBI [CHEBI:64310] ( EBI ) |
| Publication: | Shen et al., 2018 |
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