| ZFIN ID: ZDB-EXP-200331-1 |
Experiment Conditions Description: chemical treatment: palbociclib
| chemical treatment: palbociclib |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | palbociclib |
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| Synonyms: | 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one, 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, IBRANCE, palbociclib, PD 0332991, PD 332991, PD-0332991, PD0332991, UNII-G9ZF61LE7G |
| Definition: | A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer. |
| Ontology: | ChEBI [CHEBI:85993] ( EBI ) |
| Publication: | Liu et al., 2019 |
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