Gene

madd

ID
ZDB-GENE-030131-8076
Name
MAP-kinase activating death domain
Symbol
madd Nomenclature History
Previous Names
  • fj51a06
  • wu:fj51a06
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Orthologous to human MADD (MAP kinase activating death domain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With madd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
DEEAH syndrome 619004
Neurodevelopmental disorder with dysmorphic facies, impaired speech and hypotonia 619005
Associated With madd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001194 cDENN domain
Domain IPR005112 dDENN domain
Domain IPR005113 uDENN domain
Domain IPR037516 Tripartite DENN domain
Family IPR039980 MAP kinase-activating death domain protein
Homologous_superfamily IPR043153 DENN domain, C-terminal lobe
Domain Details Per Protein
Protein Length cDENN domain dDENN domain DENN domain, C-terminal lobe MAP kinase-activating death domain protein Tripartite DENN domain uDENN domain
UniProtKB:A0A1D5NSM6 1680
UniProtKB:A0A286YA84 1508
UniProtKB:A0A1D5NS97 80
UniProtKB:E7F6X3 1449
UniProtKB:A0A1D5NSF0 61
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations