PUBLICATION
Zebrafish Leopard gene as a component of the putative reaction-diffusion system
- Authors
- Asai, R., Taguchi, E., Kume, Y., Saito, M., and Kondo, S.
- ID
- ZDB-PUB-991216-3
- Date
- 1999
- Source
- Mechanisms of Development 89(1-2): 87-92 (Journal)
- Registered Authors
- Kondo, Shigeru
- Keywords
- zebrafish leopard gene; putative reaction-diffusion system
- MeSH Terms
-
- Animals
- Body Patterning/physiology*
- Catfishes/genetics
- Genes*
- Genetic Variation
- Heterozygote
- Mathematics
- Models, Genetic
- Mutation
- Pigmentation/genetics*
- Zebrafish/genetics*
- PubMed
- 10559483 Full text @ Mech. Dev.
Citation
Asai, R., Taguchi, E., Kume, Y., Saito, M., and Kondo, S. (1999) Zebrafish Leopard gene as a component of the putative reaction-diffusion system. Mechanisms of Development. 89(1-2):87-92.
Abstract
It has been suggested, on a theoretical basis, that a reaction-diffusion (RD) mechanism underlies pigment pattern formation in animals, but as yet, there is no molecular evidence for the putative mechanism. Mutations in the zebrafish gene, leopard, change the pattern from stripes to spots. Interestingly each allele gives a characteristic pattern, which varies in spot size, density and connectivity. That mutations in a single gene can generate such a variety of patterns can be understood using a RD model. All the pattern variations of leopard mutants can be generated in a simulation by changing a parameter value that corresponds to the reaction kinetics in a putative RD system. Substituting an intermediate value of the parameter makes the patterns similar to the heterozygous fish. These results suggest that the leopard gene product is a component of the putative RD mechanism.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping