ZFIN ID: ZDB-PUB-991020-9
Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila ten(m)/odd Oz gene, in the central nervous system
Mieda, M., Kikuchi, Y., Hirate, Y., Aoki, M., and Okamoto, H.
Date: 1999
Source: Mechanisms of Development   87(1-2): 223-227 (Journal)
Registered Authors: Aoki, Yasunobu, Hirate, Yoshikazu, Kikuchi, Yutaka, Mieda, Michihiro, Okamoto, Hitoshi
Keywords: zebrafish; ten-m; teneurin; ten(m)/odd Oz (dz); DOC4; CNS; rhombomere; mesencephalon; diencephalon; midbrain/hindbrain boundary; EGF-repeat; tenascin
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • DNA, Complementary/analysis
  • Drosophila
  • Drosophila Proteins*
  • Gene Expression*
  • In Situ Hybridization
  • Mesencephalon/embryology
  • Mesencephalon/metabolism*
  • Molecular Sequence Data
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism*
  • Rhombencephalon/embryology
  • Rhombencephalon/metabolism*
  • Sequence Homology, Amino Acid
  • Tenascin/metabolism*
  • Time Factors
  • Zebrafish
  • Zebrafish Proteins*
PubMed: 10495292 Full text @ Mech. Dev.
Zebrafish ten-m3 and ten-m4 encode proteins highly similar to the product of Drosophila pair-rule gene ten(m)/odd Oz (odz). Their products contain eight epidermal growth factor (EGF)-like repeats that resemble mostly those of the extracellular matrix molecule tenascin. During segmentation period, ten-m3 is expressed in the somites, notochord, pharyngeal arches, and the brain, while expression of ten-m4 is mainly restricted to the brain. In the developing brain, ten-m3 and ten-m4 expression delineates several compartments. Interestingly, ten-m3 and ten-m4 show expression patterns complementary to each other in the developing forebrain and midbrain along both rostrocaudal and dorsoventral axes, depending on developmental stages and locations.