ZFIN ID: ZDB-PUB-991020-6
Expression of a zebrafish iroquois homeobox gene, Ziro3, in the midline axial structures and central nervous system
Tan, J.T., Korzh, V., and Gong, Z.Y.
Date: 1999
Source: Mechanisms of Development   87(1-2): 165-168 (Journal)
Registered Authors: Gong, Zhiyuan, Korzh, Vladimir
Keywords: cerebellum; chordo-neural hinge; CNS; interneurons; motoneurons; rhombomere 6
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Cerebellum/metabolism*
  • DNA, Complementary/metabolism
  • Diencephalon/metabolism
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism*
  • In Situ Hybridization
  • Mesencephalon/metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism*
  • Rhombencephalon/metabolism
  • Sequence Homology, Amino Acid
  • Spinal Cord/metabolism
  • Telencephalon/metabolism
  • Time Factors
  • Zebrafish
  • Zebrafish Proteins*
PubMed: 10495280 Full text @ Mech. Dev.
We describe a zebrafish gene, Ziro3, which is highly homologous to Xenopus and mouse iroquois3. Ziro3 expression starts during gastrulation in the dorsal axial mesoderm that develops into the notochord. Later, the expression is limited to the chordo-neural hinge in the tailbud. Ziro3 expression also occurs in the central nervous system (CNS), excluding the telencephalon. The level of Ziro3 expression differs in odd and even rhombomeres. In the midbrain-hindbrain boundary (MHB) and rhombomere 6, Ziro3 transcripts appear only after the formation of the cerebellum and otic vesicle, respectively.