ZFIN ID: ZDB-PUB-990607-2
Extrinsic influences on limb muscle organisation
Blagden, C.S. and Hughes, S.M.
Date: 1999
Source: Cell and tissue research   296(1): 141-150 (Review)
Registered Authors: Blagden, Chris, Hughes, Simon M.
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning
  • Bone Morphogenetic Proteins/genetics
  • Bone Morphogenetic Proteins/physiology
  • Drosophila Proteins*
  • Ectoderm/physiology*
  • Extremities/embryology*
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/physiology
  • Hedgehog Proteins
  • Insect Proteins/genetics
  • Insect Proteins/physiology
  • Models, Biological
  • Muscle, Skeletal/embryology*
  • Signal Transduction
  • Vertebrates/embryology*
PubMed: 10199974 Full text @ Cell Tissue Res.
Skeletal muscle within the vertebrate limb originates from the somite. Much work has focussed upon the role of secreted signalling molecules of the Hedgehog, fibroblast growth factor (FGF), bone morphogenetic protein (BMP), and Wnt families plus their associated antagonists in establishing somitic cell types, yet there is no consensus on how these signals combine to influence muscle patterning. When somitic cells migrate into the limb bud, they become subject to a new set of guidance and patterning cues. Here we discuss the possible roles played by signalling proteins, particularly Hedgehogs, in guiding the cells of the limb musculature to their fate.