PUBLICATION
Mueggelone, a novel inhibitor of fish development from the fresh water cyanobacterium Aphanizomenon flos-aquae
- Authors
- Papendorf, O., König, G.M., Wright, A.D., Chorus, I., and Oberemm, A.
- ID
- ZDB-PUB-990607-17
- Date
- 1997
- Source
- Journal of natural products 60(12): 1298-1300 (Journal)
- Registered Authors
- Oberemm, Axel, Wright, Christopher V.E.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cyanobacteria/chemistry
- Cyanobacteria/metabolism*
- Fishes/growth & development*
- Growth Inhibitors/isolation & purification*
- Growth Inhibitors/pharmacology
- Lactones/isolation & purification*
- Lactones/pharmacology
- Larva/drug effects
- Larva/growth & development
- PubMed
- 9428164 Full text @ J. Nat. Prod.
Citation
Papendorf, O., König, G.M., Wright, A.D., Chorus, I., and Oberemm, A. (1997) Mueggelone, a novel inhibitor of fish development from the fresh water cyanobacterium Aphanizomenon flos-aquae. Journal of natural products. 60(12):1298-1300.
Abstract
A novel C18 lipid, containing a 10-membered lactone, mueggelone (1), was isolated from a field-collected sample of Aphanizomenon flos-aquae, together with the known compound lupenyl acetate (3). Both structures were secured using extensive spectroscopic analysis (1D and 2D NMR, MS, IR). Biological activity assessment of both compounds indicated them to have significant inhibitory effects on fish embryo larval development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping