ZFIN ID: ZDB-PUB-990406-4
Early postembryonic neural development in the zebrafish: a 3-D reconstruction of forebrain proliferation zones shows their relationship to prosomeres
Wullimann M.F., Puelles, L., and Wicht, H.
Date: 1999
Source: Eur. J. Morphol.   37: 117-121 (Journal)
Registered Authors: Wullimann, Mario F.
Keywords: none
MeSH Terms:
  • Animals
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Proliferating Cell Nuclear Antigen/metabolism
  • Prosencephalon/growth & development*
  • Prosencephalon/metabolism
  • Zebrafish/growth & development*
  • Zebrafish/metabolism
PubMed: 10342441 Full text @ Eur. J. Morphol.
Based on a section-by-section analysis of the morphology (combined silver/Nissl stain) and of the distribution of proliferation zones (immunohistochemical detection of the proliferating cell nuclear antigen) in the zebrafish (Danio rerio) forebrain at 5 days postfertilization, we created a three-dimensional reconstruction of proliferation zones of that developmental stage. The resulting model visualizes the size, number, location and morphology of forebrain proliferation zones. The latter foreshadow closely adult neuroanatomical forebrain entities. Furthermore, the detailed distribution of proliferation zones in the posterior forebrain - but not in the more anterior secondary prosencephalon - supports a segmental prosomeric organization.