ZFIN ID: ZDB-PUB-990302-48
Zebrafish as a model system for studying neuronal circuits and behavior
Fetcho, J.R. and Liu, K.S.
Date: 1998
Source: Annals of the New York Academy of Sciences   860: 333-345 (Review)
Registered Authors: Fetcho, Joseph R., Liu, Katharine S.
Keywords: Animal; Behavior, Animal; Models, Neurological; Neurons; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Zebrafish
MeSH Terms:
  • Animals
  • Behavior, Animal/physiology*
  • Models, Neurological*
  • Neurons/physiology*
  • Zebrafish/physiology*
PubMed: 9928323 Full text @ Ann N Y Acad Sci
Zebrafish are best known as a model system for studies of the genetics of development. They do, however, also offer many advantages for the study of neuronal circuitry because the larvae are transparent, allowing optical studies of neuronal activity and noninvasive photoablations of individual neurons. The combination of these optical methods with genetics through the use of mutant and transgenic lines of fish should make the zebrafish model a unique and powerful one among vertebrates. Here we review the strengths of the model and the possibilities it offers for studies of the neural basis of behavior.