ZFIN ID: ZDB-PUB-981006-6
The zebrafish organizer
Schier, A.F. and Talbot, W.S.
Date: 1998
Source: Current opinion in genetics & development   8: 464-471 (Review)
Registered Authors: Schier, Alexander, Talbot, William S.
Keywords: none
MeSH Terms:
  • Animals
  • Humans
  • Zebrafish/embryology*
PubMed: 9729724 Full text @ Curr. Opin. Genet. Dev.
Signals from the organizer play a crucial role in patterning the vertebrate embryo. Recent molecular analysis of zebrafish mutations has established an essential role for BMP2 and chordin in organizer function and has identified one-eyed pinhead as a novel EGF-like gene involved in prechordal plate and endoderm formation. In addition, embryological studies have suggested that the zebrafish organizer is induced by extraembryonic cues and have defined two novel organizing centers that pattern the nervous system along the anterior-posterior axes.