PUBLICATION
Vsx-2, a gene encoding a paired-type homeodomain, is expressed in the retina, hindbrain, and spinal cord during goldfish embryogenesis
- Authors
- Passini, M.A., Raymond, P.A., Schechter, N.
- ID
- ZDB-PUB-980910-1
- Date
- 1998
- Source
- Dev. Brain Res. 109: 129-135 (Journal)
- Registered Authors
- Passini, Marco, Raymond, Pamela, Schechter, Nisson
- Keywords
- homeobox genes; ocular retardation; visual pathway; central nervous system; zebrafish; development
- MeSH Terms
-
- Animals
- Cell Differentiation
- Gene Expression Regulation, Developmental/physiology*
- Genes, Homeobox/genetics*
- Goldfish/embryology
- Goldfish/metabolism*
- Humans
- In Situ Hybridization
- Retina/cytology
- Retina/embryology*
- Rhombencephalon/cytology
- Rhombencephalon/embryology*
- Spinal Cord/cytology
- Spinal Cord/embryology*
- PubMed
- 9729330 Full text @ Dev. Brain Res.
Citation
Passini, M.A., Raymond, P.A., Schechter, N. (1998) Vsx-2, a gene encoding a paired-type homeodomain, is expressed in the retina, hindbrain, and spinal cord during goldfish embryogenesis. Dev. Brain Res.. 109:129-135.
Abstract
Vsx-2 encodes a paired-type homeodomain and is the goldfish ortholog of the murine Chx10 gene. During development, Vsx-2 is expressed at high levels in goldfish and zebrafish retina. In addition to the retina, in situ hybridization studies using whole mount and cryosection embryos demonstrate that Vsx-2 is also expressed in subsets of neurons in the hindbrain and in the spinal cord. Expression begins approximately at the metencephalon-myelencephalon border and continues in a restricted lateral zone along the rostral-caudal axis of the spinal cord. These observations suggest a potential requirement for Vsx-2 in the specification and/or the maintenance of neurons in specific CNS regions during embryogenesis. Also discussed are other transcription factors which may act combinatorially with Vsx-2 to regulate neuronal differentiation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping