ZFIN ID: ZDB-PUB-980618-2
A new splicing variant of a type III POU gene from zebrafish encodes a POU protein with a distinct C-terminal
Lim, J.H., He, J.Y., Korzh, V., and Gong, Z.Y.
Date: 1998
Source: Biochim. Biophys. Acta Gene Struct. Exp.   1397: 253-256 (Journal)
Registered Authors: Gong, Zhiyuan, He, Jiangyan, Korzh, Vladimir
Keywords: embryo; differential splicing, teleost
MeSH Terms:
  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary/genetics
  • DNA-Binding Proteins/chemistry
  • DNA-Binding Proteins/genetics*
  • DNA-Binding Proteins/metabolism
  • Gene Expression Regulation, Developmental
  • Genetic Variation
  • Molecular Sequence Data
  • POU Domain Factors
  • Transcription Factors/chemistry
  • Transcription Factors/genetics*
  • Transcription Factors/metabolism
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
PubMed: 9582430 Full text @ Biochim. Biophys. Acta Gene Struct. Exp.
A zebrafish POU protein cDNA clone was isolated and sequenced. It appears to be a novel splicing variant of the previously reported zebrafish POU gene zp-12. There are four splicing variants and at least three of them lead to different C-terminal amino acid sequences. The four splicing variants are differentially regulated during development, indicating that they may be functionally diversified.