PUBLICATION
Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordia
- Authors
- Seo, H.C., Drivenes, O., Ellingsen, S., and Fjose, A.
- ID
- ZDB-PUB-980603-4
- Date
- 1998
- Source
- Mechanisms of Development 73: 45-57 (Journal)
- Registered Authors
- Drivenes, Oyvind, Ellingsen, Ståle, Fjose, Anders, Seo, Hee-Chan
- Keywords
- homeobox; gastrulation; forebrain; pituitary; lens placode; olfactory placode
- MeSH Terms
-
- Eye Proteins
- Eye/embryology*
- Eye/metabolism
- Amino Acid Sequence
- Zebrafish/embryology*
- PubMed
- 9545529 Full text @ Mech. Dev.
Abstract
The murine homeobox gene Six3 and its Drosophila homologue sine oculis both have regulatory functions in eye development. We report the isolation and characterization of two zebrafish genes, six3 and six6, that are closely related to the murine Six3 gene. Zebrafish six3 may be the structural orthologue, while the six6 gene is more similar with respect to embryonic expression. Transcripts of both zebrafish six genes are first detected in involuting axial mesendoderm and, subsequently, in the overlying anterior neural plate from which the optic vesicles and the forebrain will develop. Direct correspondence between six3/six6 expression boundaries and the optic vesicles indicate essential roles in defining the eye primordia. During later stages only the six6 gene displays similar features of expression in the eyes and rostral brain as reported previously for murine Six3.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping