PUBLICATION

Use of the zebrafish (Danio rerio) to define hematopoiesis

Authors
Bahary, N. and Zon, L.I.
ID
ZDB-PUB-980514-12
Date
1998
Source
Stem cells (Dayton, Ohio)   16: 89-98 (Journal)
Registered Authors
Bahary, Nathan, Zon, Leonard I.
Keywords
zebrafish; hematopoiesis; genetic mapping; genetic screens; vasculogenesis; positional cloning
MeSH Terms
  • Animals
  • Forecasting
  • Hematopoiesis*/genetics
  • Humans
  • Mutagenesis
  • Zebrafish*/genetics
PubMed
9554032 Full text @ Stem Cells
Abstract
Hematopoiesis in the vertebrate is characterized by the induction of ventral mesoderm to form hematopoietic stem cells and the eventual differentiation of these progenitors to form the peripheral blood lineages. Several genes have been implicated in the differentiation and development of hematopoietic and vascular progenitor cells, yet our understanding of the discrete steps involved in the induction of these cells from the ventral mesoderm is still incomplete. One method of delineating these processes is based on the use of lower vertebrates. The zebrafish (Danio rerio) is an especially robust vertebrate system for both isolating and characterizing genes involved in these processes. Hematopoietic mutants have been generated with defects in many of the steps of both the primitive and definitive hematopoietic programs. Cloning of the genes that underlie these mutations should yield valuable details of hematopoiesis and may have therapeutic implications for bone marrow transplantation and stem cell gene therapy.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping