PUBLICATION
Developmental biology of hematopoiesis
- Authors
- Zon, L.I.
- ID
- ZDB-PUB-980112-3
- Date
- 1995
- Source
- Blood 86: 2876-2891 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Lineage
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Hematopoiesis*
- Hematopoietic Stem Cells/cytology
- Hematopoietic System/embryology*
- Hematopoietic System/growth & development
- Mesoderm/cytology
- Mice
- Species Specificity
- Vertebrates/blood
- Vertebrates/embryology
- Yolk Sac/physiology
- PubMed
- 7579378
Citation
Zon, L.I. (1995) Developmental biology of hematopoiesis. Blood. 86:2876-2891.
Abstract
The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping