PUBLICATION
Correlation between RA-induced apoptosis and patterning defects in regenerating fins and limbs
- Authors
- Géraudie, J. and Ferretti, P.
- ID
- ZDB-PUB-971204-7
- Date
- 1997
- Source
- The International journal of developmental biology 41(3): 529-532 (Journal)
- Registered Authors
- Ferretti, Patrizia, Géraudie, Jacqueline
- Keywords
- none
- MeSH Terms
-
- Animals
- Apoptosis/drug effects*
- Apoptosis/physiology
- Body Patterning/drug effects*
- Extremities/growth & development
- Injections, Intraperitoneal
- Keratolytic Agents/pharmacology*
- Regeneration/drug effects*
- Salamandridae/physiology*
- Tretinoin/pharmacology*
- Zebrafish/physiology*
- PubMed
- 9240571
Citation
Géraudie, J. and Ferretti, P. (1997) Correlation between RA-induced apoptosis and patterning defects in regenerating fins and limbs. The International journal of developmental biology. 41(3):529-532.
Abstract
We have compared the ability of RA to induce apoptosis in regenerating fins and limbs in order to establish whether there may be a possible causal relationship between RA-induced cell death and the different patterning abnormalities observed in these two systems following RA treatment. In regenerating fins RA affects the anteroposterior axis and induces narrowing of the fin and fusion of rays. In regenerating limbs however, it mainly affects the proximodistal axis, where dose-dependent duplications of segments are observed. We report here that RA increases cell death by apoptosis both in fin and limb regenerates independently from the route of administration, but in distinct cell populations. In regenerating fins, RA-induced apoptosis is observed only in the wound epidermis, whereas in regenerating limbs significant apoptosis is observed mainly in the blastema mesenchyme. Altogether, these findings support the view that RA-induced apoptosis is causally related to the patterning defects observed in fins and limbs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping