PUBLICATION

Specification of the zebrafish nervous system by nonaxial signals

Authors
Woo, K., and Fraser, S.E.
ID
ZDB-PUB-970812-13
Date
1997
Source
Science (New York, N.Y.)   277(5323): 254-257 (Journal)
Registered Authors
Fraser, Scott E., Woo, Katherine
Keywords
none
MeSH Terms
  • Animals
  • Body Patterning*
  • Cell Transplantation
  • DNA-Binding Proteins/biosynthesis
  • Early Growth Response Protein 2
  • Ectoderm/cytology
  • Ectoderm/physiology
  • Ectoderm/transplantation
  • Endoderm/cytology
  • Endoderm/physiology
  • Endoderm/transplantation
  • Fibroblast Growth Factor 2/pharmacology
  • Gastrula/physiology*
  • Mesencephalon/embryology*
  • Mesoderm/cytology
  • Mesoderm/physiology
  • Mesoderm/transplantation
  • Morphogenesis
  • Recombinant Proteins/pharmacology
  • Rhombencephalon/embryology*
  • Stem Cells/physiology
  • Transcription Factors/biosynthesis
  • Zebrafish/embryology*
PubMed
9211857 Full text @ Science
Abstract
The organizer of the amphibian gastrula provides the neurectoderm with both neuralizing and posteriorizing (transforming) signals. In zebrafish, transplantations show that a spatially distinct transformer signal emanates from tissues other than the organizer. Cells of the germring (nonaxial mesendoderm) posteriorized forebrain progenitors when grafted nearby, resulting in an ectopic hindbrain-like structure; in contrast, cells of the organizer (axial mesendoderm) caused no posterior transformation. Local application of basic fibroblast growth factor, a candidate transformer in Xenopus, caused malformation but not hindbrain transformation in the forebrain. Thus, the zebrafish gastrula may integrate spatially distinct signals from the organizer and the germring to pattern the neural axis.
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Human Disease / Model Data
Sequence Targeting Reagents
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Orthology
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Errata and Notes