Specification of the zebrafish nervous system by nonaxial signals
- Woo, K., and Fraser, S.E.
- Science (New York, N.Y.) 277(5323): 254-257 (Journal)
- Registered Authors
- Fraser, Scott E., Woo, Katherine
- MeSH Terms
- Body Patterning*
- Cell Transplantation
- DNA-Binding Proteins/biosynthesis
- Early Growth Response Protein 2
- Fibroblast Growth Factor 2/pharmacology
- Recombinant Proteins/pharmacology
- Stem Cells/physiology
- Transcription Factors/biosynthesis
- 9211857 Full text @ Science
Woo, K., and Fraser, S.E. (1997) Specification of the zebrafish nervous system by nonaxial signals. Science (New York, N.Y.). 277(5323):254-257.
The organizer of the amphibian gastrula provides the neurectoderm with both neuralizing and posteriorizing (transforming) signals. In zebrafish, transplantations show that a spatially distinct transformer signal emanates from tissues other than the organizer. Cells of the germring (nonaxial mesendoderm) posteriorized forebrain progenitors when grafted nearby, resulting in an ectopic hindbrain-like structure; in contrast, cells of the organizer (axial mesendoderm) caused no posterior transformation. Local application of basic fibroblast growth factor, a candidate transformer in Xenopus, caused malformation but not hindbrain transformation in the forebrain. Thus, the zebrafish gastrula may integrate spatially distinct signals from the organizer and the germring to pattern the neural axis.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes