PUBLICATION
Heat shock protein gene expression during embryonic development of the zebrafish
- Authors
- Krone, P.H., Sass, J.B., and Lele, Z.
- ID
- ZDB-PUB-970423-4
- Date
- 1997
- Source
- Cellular and molecular life sciences : CMLS 53(1): 122-129 (Review)
- Registered Authors
- Krone, Patrick H., Lele, Zsolt, Sass, Jennifer
- Keywords
- zebrafish; heat shock; myogenesis; developmental biology; hsp90; hsp70; hsp47
- MeSH Terms
-
- Animals
- Gene Expression Regulation, Developmental*
- Heat-Shock Proteins/genetics*
- Heat-Shock Response
- Models, Genetic
- Zebrafish
- PubMed
- 9117992 Full text @ Cell. Mol. Life Sci.
Citation
Krone, P.H., Sass, J.B., and Lele, Z. (1997) Heat shock protein gene expression during embryonic development of the zebrafish. Cellular and molecular life sciences : CMLS. 53(1):122-129.
Abstract
Heat shock genes exhibit complex patterns of spatial and temporal regulation during embryonic development of a wide range of organisms. Our laboratory has been involved in an analysis of heat shock gene expression in the zebrafish, a model system which is now utilized extensively for the examination of early embryonic development of vertebrates. Members of the zebrafish hsp47, hsp70 and hsp90 gene families have been cloned and shown to be closely related to their counterparts in higher vertebrates. Expression of these genes has been examined using Northern blot and whole mount in situ hybridization analyses. Both the hsp47 and hsp90 genes are expressed in a highly tissue-restricted manner during normal development. The data raise a number of interesting questions regarding the function and regulation of these heat shock genes during early zebrafish development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping