PUBLICATION
Bioconcentration, metabolism and toxicity of substituted anilines in the zebrafish (Brachydanio rerio)
- Authors
- Zok, S., Gorge, G., Kalsch, W., and Nagel, R.
- ID
- ZDB-PUB-961104-11
- Date
- 1991
- Source
- The Science of the total environment 109-110: 411-21 (Journal)
- Registered Authors
- Nagel, Roland
- Keywords
- none
- MeSH Terms
-
- Aniline Compounds/metabolism*
- Aniline Compounds/pharmacokinetics
- Aniline Compounds/toxicity
- Animals
- Biotransformation
- Chromatography, High Pressure Liquid
- Kinetics
- Structure-Activity Relationship
- Zebrafish/metabolism*
- PubMed
- 1815362 Full text @ Sci. Total Environ.
Citation
Zok, S., Gorge, G., Kalsch, W., and Nagel, R. (1991) Bioconcentration, metabolism and toxicity of substituted anilines in the zebrafish (Brachydanio rerio). The Science of the total environment. 109-110:411-21.
Abstract
The LC50 (96 h) values and the bioconcentration factors (BCF) for nine anilines (aniline; 2-, 3-, 4-chloroaniline; 2-, 3-, 4-nitroaniline; 2,4- and 3,4-dichloroaniline) in the zebrafish (Brachydanio rerio) were determined. Biotransformation products of anilines in the zebrafish were analyzed by HPLC. The aim of the investigations was to find relationships between accumulation/elimination/metabolism and toxicity on the one hand and between chemical structure and biotransformation on the other. We found a good correlation of log BCF and of log Pow with log LC50. This concurs with the assumption that the internal dose determines the toxicological effect. All anilines investigated, with the exception of 2- and 4-nitroaniline, were transformed into the corresponding acetanilides. The toxicity of the compounds was not altered by biotransformation. A comparison of the extent of acetylation confirms the supposition that substituents in the ortho position sterically hinder acetylation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping