PUBLICATION
Expression pattern of zebrafish pax genes suggests a role in early brain regionalization
- Authors
- Krauss, S., Johansen, T., Korzh, V., and Fjose, A.
- ID
- ZDB-PUB-961014-634
- Date
- 1991
- Source
- Nature 353: 267-270 (Journal)
- Registered Authors
- Fjose, Anders, Johansen, Terje, Korzh, Vladimir, Krauss, Stefan
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain/embryology
- Brain/physiology*
- Cloning, Molecular
- DNA/genetics
- Embryo, Nonmammalian/physiology
- Gene Expression
- Gene Library
- Genes, Homeobox*
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Restriction Mapping
- Sequence Homology, Nucleic Acid
- Transcription, Genetic
- Zebrafish/genetics*
- PubMed
- 1680220 Full text @ Nature
Citation
Krauss, S., Johansen, T., Korzh, V., and Fjose, A. (1991) Expression pattern of zebrafish pax genes suggests a role in early brain regionalization. Nature. 353:267-270.
Abstract
In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebrates such as the zebrafish, Brachydanio rerio, may reveal remnants of such subdivisions. We have isolated complementary DNA clones for two zebrafish pax genes related to Drosophila and mouse paired-box-containing segmentation genes. The expression of these two genes is confined to specific regions in the embryonic forebrain and midbrain. Strikingly, the borders of expression of the two pax genes coincide with morphological landmarks corresponding to the primary axon tracts that are generated in the embryonic brain a few hours after the initiation of expression of these genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping