|ZFIN ID: ZDB-PUB-961014-422|
Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression
Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B.
|Source:||Science (New York, N.Y.) 250: 802-805 (Journal)|
|Registered Authors:||BreMiller, Ruth, Hatta, Kohei, Kimmel, Charles B., Schilling, Tom|
|PubMed:||1978412 Full text @ Science|
Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B. (1990) Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression. Science (New York, N.Y.). 250:802-805.
ABSTRACTMolecules that determine the specific features of individual muscles in vertebrates are unknown. Antibody labeling studies described here revealed a molecular difference among muscles in the zebrafish head, in that two functionally related jaw muscles (the levator arcus palatini and the dilator operculi), and not other head muscles, expressed engrailed-homeodomain proteins. Expression began in mesoderm-derived muscle-precursor cells in the paraxial mesenchyme and continued during muscle morphogenesis and differentiation. Growth cones of trigeminal motoneurons that innervate these muscles associated with the precursors within a few hours of the time they began to express engrailed. It is proposed that the engrailed proteins in these cells establish muscle identity and neuromuscular target recognition.
- Antibodies (1)