ZFIN ID: ZDB-PUB-961014-422
Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression
Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B.
Date: 1990
Source: Science (New York, N.Y.)   250: 802-805 (Journal)
Registered Authors: BreMiller, Ruth, Hatta, Kohei, Kimmel, Charles B., Schilling, Tom
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation
  • DNA-Binding Proteins/blood*
  • Gene Expression Regulation*
  • Genes, Homeobox*
  • Jaw/embryology*
  • Morphogenesis
  • Motor Neurons/cytology
  • Muscles/embryology*
  • Muscles/innervation
  • Muscles/metabolism
  • Zebrafish/embryology*
PubMed: 1978412 Full text @ Science
Molecules that determine the specific features of individual muscles in vertebrates are unknown. Antibody labeling studies described here revealed a molecular difference among muscles in the zebrafish head, in that two functionally related jaw muscles (the levator arcus palatini and the dilator operculi), and not other head muscles, expressed engrailed-homeodomain proteins. Expression began in mesoderm-derived muscle-precursor cells in the paraxial mesenchyme and continued during muscle morphogenesis and differentiation. Growth cones of trigeminal motoneurons that innervate these muscles associated with the precursors within a few hours of the time they began to express engrailed. It is proposed that the engrailed proteins in these cells establish muscle identity and neuromuscular target recognition.