PUBLICATION

Coordinate embryonic expression of three zebrafish engrailed genes

Authors
Ekker, M., Wegner, J., Akimenko, M.A., and Westerfield, M.
ID
ZDB-PUB-961014-283
Date
1992
Source
Development (Cambridge, England)   116: 1001-1010 (Journal)
Registered Authors
Akimenko, Marie-Andree, Ekker, Marc, Wegner, Jeremy, Westerfield, Monte
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Central Nervous System/embryology*
  • Conserved Sequence
  • Gene Expression/genetics*
  • Genes, Homeobox/genetics*
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Muscles/embryology
  • Sequence Homology, Amino Acid
  • Zebrafish/embryology
  • Zebrafish/genetics*
PubMed
1363539
Abstract
We have identified three genes, expressed in zebrafish embryos, that are members of the engrailed gene family. On the basis of sequence comparisons and analyses of their expression patterns, we suggest that two of these genes, eng2 and eng3, are closely related to the En-2 gene of other vertebrates. The third gene, eng1, is probably the zebrafish homolog of En-1. Subsets of cells at the developing junction between the midbrain and hindbrain express three different combinations of these genes, revealing a previously unknown complexity of this region of the CNS. Other cells, for example, jaw and myotomal muscle precursors, express two of the three genes in combinations which, in the myotomal muscles, change during development. Cells in the developing hindbrain and fins express only a single engrailed gene. We propose that the fates and patterning of these cells may be regulated by the coordinate expression of particular combinations of these closely related homeoproteins.
Genes / Markers
Figures
Figure Gallery
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes