PUBLICATION
The spt-1 mutation alters the segmental arrangement and axonal development of identified neurons in the spinal cord of the embryonic zebrafish
- Authors
- Eisen, J.S. and Pike, S.H.
- ID
- ZDB-PUB-961014-274
- Date
- 1991
- Source
- Neuron 6: 767-776 (Journal)
- Registered Authors
- Eisen, Judith S.
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/physiology
- Cell Count
- Interneurons/cytology
- Interneurons/physiology
- Mesoderm/physiology
- Motor Neurons/cytology*
- Motor Neurons/physiology
- Muscles/embryology
- Muscles/innervation
- Mutation*
- Neurons, Afferent/cytology
- Neurons, Afferent/physiology
- Spinal Cord/cytology
- Spinal Cord/embryology*
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 2025428 Full text @ Neuron
Citation
Eisen, J.S. and Pike, S.H. (1991) The spt-1 mutation alters the segmental arrangement and axonal development of identified neurons in the spinal cord of the embryonic zebrafish. Neuron. 6:767-776.
Abstract
We examined the arrangement and development of identified neurons in zebrafish embryos homozygous for the mutation spt-1, which acts autonomously and specifically to alter the development of precursors of trunk segmented mesoderm, resulting in muscle-deficient myotomes. We found that the mutation alters the morphology, number, and arrangement of identified motoneurons. By transplanting identified motoneurons between wild-type and mutant embryos, we found that the effect of the mutation was nonautonomous. We suggest that the segmental arrangement and proper axonal development of motoneurons may result from interactions with segmented mesoderm.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping