PUBLICATION
Circadian regulation of melatonin production in cultured zebrafish pineal and retina
- Authors
- Cahill, G.M.
- ID
- ZDB-PUB-961014-155
- Date
- 1996
- Source
- Brain research 708: 177-181 (Journal)
- Registered Authors
- Cahill, Greg
- Keywords
- none
- MeSH Terms
-
- Animals
- Circadian Rhythm*
- Darkness
- Female
- In Vitro Techniques
- Kinetics
- Light
- Male
- Melatonin/biosynthesis*
- Pineal Gland/physiology*
- Radioimmunoassay
- Retina/physiology*
- Time
- Zebrafish
- PubMed
- 8720875 Full text @ Brain Res.
Citation
Cahill, G.M. (1996) Circadian regulation of melatonin production in cultured zebrafish pineal and retina. Brain research. 708:177-181.
Abstract
Melatonin release was measured from zebrafish pineal organs and retinas maintained in flow-through culture. Pineal organs released melatonin in a strong circadian rhythm through 5 days in constant darkness, and the phase of this rhythm was reset by in vitro exposure to phase-shifted light cycles. In contrast, the retinal melatonin rhythm rapidly damped out in constant darkness, even in the presence of (phase-shifted) light cycles. The zebrafish pineal should be useful for in vitro studies of vertebrate circadian clock mechanisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping