PUBLICATION
A transient neurohormonal circuit controls hatching in fish
- Authors
- Gajbhiye, D.S., Fernandes, G.L., Oz, I., Nahmias, Y., Golan, M.
- ID
- ZDB-PUB-241206-4
- Date
- 2024
- Source
- Science (New York, N.Y.) 386: 117311781173-1178 (Journal)
- Registered Authors
- Gajbhiye, Deodatta, Golan, Matan
- Keywords
- none
- MeSH Terms
-
- Neurons*/physiology
- Neurosecretory Systems*/physiology
- Zebrafish*/physiology
- Thyrotropin-Releasing Hormone*/metabolism
- Animals
- Oviparity*/genetics
- Oviparity*/physiology
- Embryo, Nonmammalian/metabolism
- PubMed
- 39636978 Full text @ Science
Citation
Gajbhiye, D.S., Fernandes, G.L., Oz, I., Nahmias, Y., Golan, M. (2024) A transient neurohormonal circuit controls hatching in fish. Science (New York, N.Y.). 386:117311781173-1178.
Abstract
Hatching is a critical event in the life history of oviparous species. The decision to hatch is often carefully timed to coincide with favorable conditions that will improve survival through early life stages. However, how the relevant cues are relayed to trigger hatching remains unknown. In this work, we show that thyrotropin-releasing hormone (Trh) is the neuroendocrine activator of hatching in zebrafish. To elicit hatching, Trh neurons form a transient circuit that deposits the peptide into the embryo's circulation. Trh also activates hatching in a distantly related fish species that separated more than 200 million years ago. Our results reveal an evolutionarily conserved neuroendocrine circuit that controls a major life event in oviparous fish species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping