PUBLICATION
The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue
- Authors
- Morocho-Jaramillo, P.A., Kotlar-Goldaper, I., Zakarauskas-Seth, B.I., Purfürst, B., Filosa, A., Sawamiphak, S.
- ID
- ZDB-PUB-240321-2
- Date
- 2024
- Source
- Cell Reports 43: 113955113955 (Journal)
- Registered Authors
- Filosa, Alessandro, Sawamiphak, Suphansa
- Keywords
- CP: Developmental biology, CP: Metabolism, ectotherm, epicardial adipose tissue, thermogenic, transcriptome, zebrafish
- Datasets
- GEO:GSE227670
- MeSH Terms
-
- Animals
- Adipose Tissue/metabolism
- Thermogenesis
- Pericardium/metabolism
- Epicardial Adipose Tissue
- Adipose Tissue, White/metabolism
- Adipose Tissue, Beige*/metabolism
- Adipose Tissue, Brown/metabolism
- Humans
- Aged
- Zebrafish*
- PubMed
- 38507414 Full text @ Cell Rep.
Citation
Morocho-Jaramillo, P.A., Kotlar-Goldaper, I., Zakarauskas-Seth, B.I., Purfürst, B., Filosa, A., Sawamiphak, S. (2024) The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue. Cell Reports. 43:113955113955.
Abstract
Epicardial adipose tissue (eAT) is a metabolically active fat depot that has been associated with a wide array of cardiac homeostatic functions and cardiometabolic diseases. A full understanding of its diverse physiological and pathological roles is hindered by the dearth of animal models. Here, we show, in the heart of an ectothermic teleost, the zebrafish, the existence of a fat depot localized underneath the epicardium, originating from the epicardium and exhibiting the molecular signature of beige adipocytes. Moreover, a subset of adipocytes within this cardiac fat tissue exhibits primitive thermogenic potential. Transcriptomic profiling and cross-species analysis revealed elevated glycolytic and cardiac homeostatic gene expression with downregulated obesity and inflammatory hallmarks in the teleost eAT compared to that of lean aged humans. Our findings unveil epicardium-derived beige fat in the heart of an ectotherm considered to possess solely white adipocytes for energy storage and identify pathways that may underlie age-driven remodeling of human eAT.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping