PUBLICATION

The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue

Authors
Morocho-Jaramillo, P.A., Kotlar-Goldaper, I., Zakarauskas-Seth, B.I., Purfürst, B., Filosa, A., Sawamiphak, S.
ID
ZDB-PUB-240321-2
Date
2024
Source
Cell Reports   43: 113955113955 (Journal)
Registered Authors
Filosa, Alessandro, Sawamiphak, Suphansa
Keywords
CP: Developmental biology, CP: Metabolism, ectotherm, epicardial adipose tissue, thermogenic, transcriptome, zebrafish
Datasets
GEO:GSE227670
MeSH Terms
  • Thermogenesis
  • Adipose Tissue, White/metabolism
  • Adipose Tissue/metabolism
  • Zebrafish*
  • Adipose Tissue, Beige*/metabolism
  • Adipose Tissue, Brown/metabolism
  • Epicardial Adipose Tissue
  • Humans
  • Aged
  • Animals
  • Pericardium/metabolism
(all 11)
PubMed
38507414 Full text @ Cell Rep.
Abstract
Epicardial adipose tissue (eAT) is a metabolically active fat depot that has been associated with a wide array of cardiac homeostatic functions and cardiometabolic diseases. A full understanding of its diverse physiological and pathological roles is hindered by the dearth of animal models. Here, we show, in the heart of an ectothermic teleost, the zebrafish, the existence of a fat depot localized underneath the epicardium, originating from the epicardium and exhibiting the molecular signature of beige adipocytes. Moreover, a subset of adipocytes within this cardiac fat tissue exhibits primitive thermogenic potential. Transcriptomic profiling and cross-species analysis revealed elevated glycolytic and cardiac homeostatic gene expression with downregulated obesity and inflammatory hallmarks in the teleost eAT compared to that of lean aged humans. Our findings unveil epicardium-derived beige fat in the heart of an ectotherm considered to possess solely white adipocytes for energy storage and identify pathways that may underlie age-driven remodeling of human eAT.
Genes / Markers
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Expression
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Phenotype
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
cz1701TgTransgenic Insertion
    pd42TgTransgenic Insertion
      s896TgTransgenic Insertion
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        Human Disease / Model
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        Sequence Targeting Reagents
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        Antibodies
        Orthology
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        Engineered Foreign Genes
        Marker Marker Type Name
        CreEFGCre
        EGFPEFGEGFP
        mCherryEFGmCherry
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        Citation
        Morocho-Jaramillo, P.A., Kotlar-Goldaper, I., Zakarauskas-Seth, B.I., Purfürst, B., Filosa, A., Sawamiphak, S. (2024) The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue. Cell Reports. 43:113955113955.