PUBLICATION
Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae
- Authors
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R.
- ID
- ZDB-PUB-240313-8
- Date
- 2024
- Source
- International Journal of Molecular Sciences 25(5): (Journal)
- Registered Authors
- Zhang, Ruilin
- Keywords
- NAFLD, amoxicillin: clavulanic acid, developmental toxicity, disease susceptibility
- MeSH Terms
-
- Larva
- Non-alcoholic Fatty Liver Disease*/metabolism
- Amoxicillin/metabolism
- Disease Susceptibility/metabolism
- Liver/metabolism
- Animals
- Zebrafish
- PubMed
- 38473993 Full text @ Int. J. Mol. Sci.
Citation
Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):.
Abstract
Amoxicillin is commonly used in clinical settings to target bacterial infection and is frequently prescribed during pregnancy. Investigations into its developmental toxicity and effects on disease susceptibility are not comprehensive. Our present study examined the effects of embryonic amoxicillin exposure on liver development and function, especially the effects on susceptibility to non-alcoholic fatty liver disease (NAFLD) using zebrafish as an animal model. We discovered that embryonic amoxicillin exposure did not compromise liver development, nor did it induce liver toxicity. However, co-treatment of amoxicillin and clavulanic acid diminished BESP expression, caused bile stasis and induced liver toxicity. Embryonic amoxicillin exposure resulted in elevated expression of lipid synthesis genes and exacerbated hepatic steatosis in a fructose-induced NAFLD model, indicating embryonic amoxicillin exposure increased susceptibility to NAFLD in zebrafish larvae. In summary, this research broadens our understanding of the risks of amoxicillin usage during pregnancy and provides evidence for the impact of embryonic amoxicillin exposure on disease susceptibility in offspring.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping