PUBLICATION

Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae

Authors
Gao, P., Chang, C., Liang, J., Du, F., Zhang, R.
ID
ZDB-PUB-240313-8
Date
2024
Source
International Journal of Molecular Sciences   25(5): (Journal)
Registered Authors
Zhang, Ruilin
Keywords
NAFLD, amoxicillin: clavulanic acid, developmental toxicity, disease susceptibility
MeSH Terms
  • Disease Susceptibility/metabolism
  • Animals
  • Larva
  • Amoxicillin/metabolism
  • Zebrafish
  • Liver/metabolism
  • Non-alcoholic Fatty Liver Disease*/metabolism
(all 7)
PubMed
38473993 Full text @ Int. J. Mol. Sci.
Abstract
Amoxicillin is commonly used in clinical settings to target bacterial infection and is frequently prescribed during pregnancy. Investigations into its developmental toxicity and effects on disease susceptibility are not comprehensive. Our present study examined the effects of embryonic amoxicillin exposure on liver development and function, especially the effects on susceptibility to non-alcoholic fatty liver disease (NAFLD) using zebrafish as an animal model. We discovered that embryonic amoxicillin exposure did not compromise liver development, nor did it induce liver toxicity. However, co-treatment of amoxicillin and clavulanic acid diminished BESP expression, caused bile stasis and induced liver toxicity. Embryonic amoxicillin exposure resulted in elevated expression of lipid synthesis genes and exacerbated hepatic steatosis in a fructose-induced NAFLD model, indicating embryonic amoxicillin exposure increased susceptibility to NAFLD in zebrafish larvae. In summary, this research broadens our understanding of the risks of amoxicillin usage during pregnancy and provides evidence for the impact of embryonic amoxicillin exposure on disease susceptibility in offspring.
Genes / Markers
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Expression
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
gz15TgTransgenic Insertion
    s957TgTransgenic Insertion
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      Human Disease / Model
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      Fish
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      Antibodies
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      Engineered Foreign Genes
      Marker Marker Type Name
      DsRedEFGDsRed
      EGFPEFGEGFP
      mCherryEFGmCherry
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      Citation
      Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):.