PUBLICATION

Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

Authors
Shang, C.F., Wang, Y.F., Zhao, M.T., Fan, Q.X., Zhao, S., Qian, Y., Xu, S.J., Mu, Y., Hao, J., Du, J.L.
ID
ZDB-PUB-240312-10
Date
2024
Source
Nature Neuroscience   27(5): 1014-1018 (Journal)
Registered Authors
Du, Jiu Lin
Keywords
none
MeSH Terms
  • Animals
  • Brain*/diagnostic imaging
  • Brain*/physiology
  • Computer Systems
  • Image Processing, Computer-Assisted/methods
  • Neuroimaging/methods
  • Neurons*/physiology
  • Larva
  • Zebrafish*
(all 9)
PubMed
38467902 Full text @ Nat. Neurosci.
Abstract
Large-scale imaging of neuronal activities is crucial for understanding brain functions. However, it is challenging to analyze large-scale imaging data in real time, preventing closed-loop investigation of neural circuitry. Here we develop a real-time analysis system with a field programmable gate array-graphics processing unit design for an up to 500-megabyte-per-second image stream. Adapted to whole-brain imaging of awake larval zebrafish, the system timely extracts activity from up to 100,000 neurons and enables closed-loop perturbations of neural dynamics.
Genes / Markers
Figures
No images available
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Shang, C.F., Wang, Y.F., Zhao, M.T., Fan, Q.X., Zhao, S., Qian, Y., Xu, S.J., Mu, Y., Hao, J., Du, J.L. (2024) Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics. Nature Neuroscience. 27(5):1014-1018.