PUBLICATION
Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health
- Authors
- Yang, G., Gou, D., Bu, L.K., Wei, X.Y., Hu, H., Huo, W.B., Sultan, M., Pei, D.S.
- ID
- ZDB-PUB-240224-7
- Date
- 2024
- Source
- Toxics 12(2): (Journal)
- Registered Authors
- Pei, Desheng
- Keywords
- developmental toxicity, histopathological image analysis, oxidative stress, transcriptomic analysis, zebrafish
- MeSH Terms
- none
- PubMed
- 38393245 Full text @ Toxics
Citation
Yang, G., Gou, D., Bu, L.K., Wei, X.Y., Hu, H., Huo, W.B., Sultan, M., Pei, D.S. (2024) Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health. Toxics. 12(2):.
Abstract
Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a conductive polymer commonly used in various technological applications. However, its impact on aquatic ecosystems remains largely unexplored. In this study, we investigated the toxicity effects of PEDOT:PSS on zebrafish. We first determined the lethal concentration (LC50) of PEDOT:PSS in zebrafish and then exposed AB-type zebrafish embryos to different concentrations of PEDOT:PSS for 120 h. Our investigation elucidated the toxicity effects of zebrafish development, including morphological assessments, heart rate measurements, behavioral analysis, transcriptome profiling, and histopathological analysis. We discovered that PEDOT:PSS exhibited detrimental effects on the early developmental stages of zebrafish, exacerbating the oxidative stress level, suppressing zebrafish activity, impairing cardiac development, and causing intestinal cell damage. This study adds a new dimension to the developmental toxicity of PEDOT:PSS in zebrafish. Our findings contribute to our understanding of the ecological repercussions of PEDOT:PSS and highlight the importance of responsible development and application of novel materials in our rapidly evolving technological landscape.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping