PUBLICATION
Implications of exposure route for the bioaccumulation potential of nanopolystyrene particles
- Authors
- Pitt, J.A., Hahn, M.E., Aluru, N.
- ID
- ZDB-PUB-240111-1
- Date
- 2024
- Source
- Chemosphere 351: 141133 (Journal)
- Registered Authors
- Hahn, Mark E.
- Keywords
- none
- MeSH Terms
-
- Animals
- Bioaccumulation
- Larva/metabolism
- Microplastics/metabolism
- Microplastics/toxicity
- Plastics*
- Water Pollutants, Chemical*/analysis
- Water Pollutants, Chemical*/toxicity
- Zebrafish/metabolism
- PubMed
- 38199495 Full text @ Chemosphere
Citation
Pitt, J.A., Hahn, M.E., Aluru, N. (2024) Implications of exposure route for the bioaccumulation potential of nanopolystyrene particles. Chemosphere. 351:141133.
Abstract
Microplastics and nanoplastics are found in marine biota across a wide range of trophic levels and environments. While a large portion of the information about plastic exposure comes from gastrointestinal (GI) data, the relevance of particle accumulation from an oral exposure compared with other types of exposure (e.g. dermal, respiratory) is unknown. To address this gap in knowledge, larval zebrafish (7 days post fertilization) were exposed to two different sizes of nanoplastics through either oral gavage or a waterborne exposure. Larvae were tracked for 48 h post exposure (hpe) to assess the migration and elimination of plastics. Larvae eliminated orally gavaged nanoplastics within 48 hpe. Oral gavage showed limited particle movement from the GI tract into other tissues. In contrast, waterborne nanoplastic-exposed larvae displayed notable fluorescence in tissues outside of the GI tract. The 50 nm waterborne-exposed larvae retained the particles past 48 hpe, and showed accumulation with neuromasts. For both sizes of plastic particles, the nanoplastics were eliminated from non-GI tract tissues by 24 hpe. Our results suggest that waterborne exposure leads to greater accumulation of plastic in comparison to oral exposure, suggesting that plastic accumulation in certain tissues is greater via routes of exposure other than oral consumption.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping