PUBLICATION
Predictive neural computations in the cerebellum contribute to motor planning and faster behavioral responses in larval zebrafish
- Authors
- Narayanan, S., Varma, A., Thirumalai, V.
- ID
- ZDB-PUB-240105-11
- Date
- 2024
- Source
- Science advances 10: eadi6470eadi6470 (Journal)
- Registered Authors
- Narayanan, Sriram, Thirumalai, Vatsala, Varma, Aalok
- Keywords
- none
- MeSH Terms
-
- Animals
- Cerebellum*/physiology
- Larva/physiology
- Neurons/physiology
- Purkinje Cells/physiology
- Zebrafish*/physiology
- PubMed
- 38170763 Full text @ Sci Adv
Citation
Narayanan, S., Varma, A., Thirumalai, V. (2024) Predictive neural computations in the cerebellum contribute to motor planning and faster behavioral responses in larval zebrafish. Science advances. 10:eadi6470eadi6470.
Abstract
The ability to predict the future based on past experience lies at the core of the brain's ability to adapt behavior. However, the neural mechanisms that participate in generating and updating predictions are not clearly understood. Further, the evolutionary antecedents and the prevalence of predictive processing among vertebrates are even less explored. Here, we show evidence of predictive processing via the involvement of cerebellar circuits in larval zebrafish. We presented stereotyped optic flow stimuli to larval zebrafish to evoke swims and discovered that lesioning the cerebellum abolished prediction-dependent modulation of swim latency. When expectations of optic flow direction did not match with reality, error signals arrive at Purkinje cells via the olivary climbing fibers, whereas granule cells and Purkinje cells encode signals of expectation. Strong neural representations of expectation correlate with faster swim responses and vice versa. In sum, our results show evidence for predictive processing in nonmammalian vertebrates with the involvement of cerebellum, an evolutionarily conserved brain structure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping