PUBLICATION
Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair
- Authors
- Sun, J., Wu, Q., Wei, Y., Zhao, W., Lv, H., Peng, W., Zheng, J., Chen, Y., Wang, Z., Pan, Y., Xue, Y.
- ID
- ZDB-PUB-231224-20
- Date
- 2023
- Source
- Life (Basel, Switzerland) 13(12): (Journal)
- Registered Authors
- Xue, Yu
- Keywords
- BMP, VEGF, glucosamine hydrochloride, impairment repair, vascular development, zebrafish
- MeSH Terms
- none
- PubMed
- 38137931 Full text @ Life (Basel)
Citation
Sun, J., Wu, Q., Wei, Y., Zhao, W., Lv, H., Peng, W., Zheng, J., Chen, Y., Wang, Z., Pan, Y., Xue, Y. (2023) Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair. Life (Basel, Switzerland). 13(12):.
Abstract
Glucosamine hydrochloride (GAH) is a natural component of glycoproteins present in almost all human tissues and participates in the construction of human tissues and cell membranes. GAH has a wide range of biological activities, particularly in anti-inflammatory and osteogenic damage repair. At present, little is known about how GAH functions in angiogenesis. To determine the role of GAH on vascular development and impairment repair, we used the inhibitors VRI, DMH1, and dorsomorphin (DM) to construct vascular-impaired models in Tg(kdrl: mCherry) transgenic zebrafish. We then treated with GAH and measured its repair effects on vascular impairment through fluorescence intensity, mRNA, and protein expression levels of vascular-specific markers. Our results indicate that GAH promotes vascular development and repairs impairment by regulating the vascular endothelial growth factor (VEGF) signaling pathway through modulation of bone morphogenetic protein (BMP) signaling. This study provides an experimental basis for the development of GAH as a drug to repair vascular diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping