PUBLICATION
Effects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio)
- Authors
- Piarulli, S., Riedel, J.A., Fossum, F.N., Kermen, F., Hansen, B.H., Kvæstad, B., Olsvik, P.A., Farkas, J.
- ID
- ZDB-PUB-231220-9
- Date
- 2023
- Source
- Chemosphere 350: 140950 (Journal)
- Registered Authors
- Kermen, Florence
- Keywords
- Ecotoxicity, Embryotoxicity, Fish, Neurotoxicity, REE, Rare earth elements
- MeSH Terms
-
- Animals
- Contrast Media/toxicity
- Gadolinium/toxicity
- Gadolinium DTPA
- Larva
- Magnetic Resonance Imaging
- Metals, Rare Earth*
- Perciformes*
- Water Pollutants, Chemical*/analysis
- Water Pollutants, Chemical*/toxicity
- Zebrafish
- PubMed
- 38114019 Full text @ Chemosphere
Citation
Piarulli, S., Riedel, J.A., Fossum, F.N., Kermen, F., Hansen, B.H., Kvæstad, B., Olsvik, P.A., Farkas, J. (2023) Effects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio). Chemosphere. 350:140950.
Abstract
Gadolinium (Gd) is one of the rare earth elements (REY) and is widely used in magnetic resonance imaging (MRI) contrast agents. Anthropogenic Gd enrichment has frequently been found in wastewater treatment plant effluents in industrialised countries, rising concerns regarding effects on aquatic biota. This study investigates the acute toxicity and sublethal effects of Gd in two forms, as inorganic salt (GdCl3) and as Gd-based contrast agent (GBCA), on early life stages of zebrafish (Danio rerio). Nominal exposure concentrations ranged from 3 to 3000 μg L-1, with an exposure duration of 96 h. None of the two tested compounds were acutely toxic to embryos and larvae. Similarly, we did not observe any effects on larval development and locomotive behaviour. However, we found significant changes in the brain activity of larvae exposed to the highest concentrations of GdCl3 and the GBCA. Our findings show that Gd can have sublethal effects on developing fish at lower concentrations than reported previously, highlighting the necessity of investigating the long-term fate and effects of GBCAs released into the aquatic environment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping