PUBLICATION
Neural Endophenotype Assessment in Zebrafish Larvae Using Optomotor and ZebraBox Locomotion Assessment
- Authors
- Xie, J., Goodbourn, P., Sztal, T., Jusuf, P.R.
- ID
- ZDB-PUB-231210-9
- Date
- 2024
- Source
- Methods in molecular biology (Clifton, N.J.) 2746: 213224213-224 (Chapter)
- Registered Authors
- Jusuf, Patricia, Sztal, Tamar Esther, Xie, Jiaheng
- Keywords
- Optomotor response function, Psychophysics test, Visual processing, Visual swimming behavior, Zebrafish vision
- MeSH Terms
-
- Animals
- Endophenotypes*
- Larva/genetics
- Locomotion
- Swimming/physiology
- Zebrafish*/genetics
- PubMed
- 38070092 Full text @ Meth. Mol. Biol.
Citation
Xie, J., Goodbourn, P., Sztal, T., Jusuf, P.R. (2024) Neural Endophenotype Assessment in Zebrafish Larvae Using Optomotor and ZebraBox Locomotion Assessment. Methods in molecular biology (Clifton, N.J.). 2746:213224213-224.
Abstract
Due to the highly conserved genetics across the central nervous system, the easily probed visual system can act as an endophenotype for assessing neurological function. Here, we describe a psychophysics approach to assess visually driven swimming behavior in the high-throughput zebrafish genetic model system. We use the optomotor response test together with general locomotion behavior to assess neural processing while excluding motor defects related to muscle function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping