PUBLICATION
Long non-coding RNA Mir17hg positively regulates melanogenesis by inhibiting TGFβ receptor 2 under psychological stress
- Authors
- Dong, J., Peng, Z., Chen, M., Lai, Y., Zhang, X., Yu, M., Zhong, H., Liu, J., Yue, Y., Shang, J.
- ID
- ZDB-PUB-230915-56
- Date
- 2023
- Source
- The Journal of investigative dermatology 144(2): 358-368.e10 (Journal)
- Registered Authors
- Dong, Jing, Shang, Jing, Yue, Yunyun
- Keywords
- Mir17hg, TGFβR2, chronic restraint stress, melanogenesis
- MeSH Terms
-
- Animals
- Melanocytes/metabolism
- Melanogenesis
- Mice
- Mice, Inbred C57BL
- Phosphatidylinositol 3-Kinases/metabolism
- RNA, Long Noncoding*/genetics
- RNA, Long Noncoding*/metabolism
- Stress, Psychological/genetics
- Transforming Growth Factor beta/metabolism
- Vitiligo*/pathology
- Zebrafish/metabolism
- PubMed
- 37709007 Full text @ J. Invest. Dermatol.
Citation
Dong, J., Peng, Z., Chen, M., Lai, Y., Zhang, X., Yu, M., Zhong, H., Liu, J., Yue, Y., Shang, J. (2023) Long non-coding RNA Mir17hg positively regulates melanogenesis by inhibiting TGFβ receptor 2 under psychological stress. The Journal of investigative dermatology. 144(2):358-368.e10.
Abstract
Vitiligo is a common skin depigmentation disorder characterized by the patchy loss of skin color. Nowadays, it's recognized as being correlated with multiple genetic factors as well as the psychological conditions of individuals. Long non-coding RNAs (lncRNAs) have been reported to underlie the pathogenesis of vitiligo; however, the role of lncRNAs in the stress-related depigmentation process remains largely unknown. In this study, the inhibition of melanocyte function was observed in C57BL/6J mice modeled by chronic restraint stress. Furthermore, downregulation of the expression of the lncRNA Mir17hg was identified by RNA sequencing. The regulatory role of Mir17hg in melanogenesis was also investigated in melanocytes and zebrafish embryos by overexpression or knockdown. Finally, transforming growth factor β receptor II (TGFβR2) was shown to be a downstream target in Mir17hg-mediated melanogenesis regulation, in which the classical TGFβ/SMAD signaling cascade and the PI3K/AKT/mTOR signaling cascade play important roles. In conclusion, our results revealed an important regulatory role of Mir17hg in melanogenesis via inhibition of TGFβR2, which can provide a potential therapeutic target for treating skin depigmentation disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping