PUBLICATION
Altered ovarian transcriptome is linked to early mortality and abnormalities in zebrafish embryos after maternal exposure to gamma irradiation
- Authors
- Guirandy, N., Armant, O., Frelon, S., Pierron, F., Geffroy, B., Daffe, G., Houdelet, C., Gonzalez, P., Simon, O.
- ID
- ZDB-PUB-230827-65
- Date
- 2023
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 262: 106660106660 (Journal)
- Registered Authors
- Armant, Olivier
- Keywords
- Cortisol, Irradiation, Maternal transcripts, Multigenerational, Vitellogenin, Zebrafish
- MeSH Terms
-
- Animals
- Female
- Humans
- Maternal Exposure/adverse effects
- Ovary
- Transcriptome
- Water Pollutants, Chemical*/toxicity
- Zebrafish*/genetics
- PubMed
- 37633173 Full text @ Aquat. Toxicol.
Citation
Guirandy, N., Armant, O., Frelon, S., Pierron, F., Geffroy, B., Daffe, G., Houdelet, C., Gonzalez, P., Simon, O. (2023) Altered ovarian transcriptome is linked to early mortality and abnormalities in zebrafish embryos after maternal exposure to gamma irradiation. Aquatic toxicology (Amsterdam, Netherlands). 262:106660106660.
Abstract
Recent laboratory studies focusing on multigenerational approach demonstrated drastic phenotypic effects after chronic fish irradiation exposure. No irradiation effect at phenotypic scale was observed for F0 (reproductive performances) while early mortality and malformations were observed in F1 offspring whether they were irradiated or not. The objective was to study molecular mechanisms likely to be involved in these phenotypic effects induced by parental irradiation. Thus, F0 adult zebrafish were irradiated for ten days until reproduction and maternal involvement in offspring development was assessed. Levels of maternal provided cortisol and vitellogenin, needed for embryo development, were not impacted by irradiation. However, maternal transcriptome highlighted irradiation effect on processes involved in oocyte development, as well as on essential maternal factors needed for offspring development. Therefore, this study highlighted the importance of parental exposure on offspring fate and of the importance of multigenerational exposure in risk assessment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping