PUBLICATION

Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Authors
Overman, J., Fontaine, F., Moustaqil, M., Mittal, D., Sierecki, E., Sacilotto, N., Zuegg, J., Robertson, A.A.B., Holmes, K., Salim, A.A., Mamidyala, S., Butler, M.S., Robinson, A.S., Lesieur, E., Johnston, W., Alexandrov, K., Black, B.L., Hogan, B.M., De Val, S., Capon, R.J., Carroll, J.S., Bailey, T.L., Koopman, P., Jauch, R., Cooper, M.A., Gambin, Y., Francois, M.
ID
ZDB-PUB-230810-50
Date
2023
Source
eLIFE   12: (Journal)
Registered Authors
Black, Brian, De Val, Sarah, Hogan, Ben M., Sacilotto, Natalia
Keywords
biochemistry, chemical biology, mouse, zebrafish
MeSH Terms
none
PubMed
37551662 Full text @ Elife
Abstract
Following a research integrity investigation by QIMR Berghofer Medical Research Institute, Brisbane, Australia (QIMRB), into papers containing experiments conducted by Professor Mark Smyth at QIMRB, it was concluded that both parts of Figure 4—figure supplement 1 were based on fabricated data. One figure that was believed to be based on fabricated data, Figure 4—figure supplement 1, has been clearly identified. Accordingly, Figure 4—figure supplement 1 has been removed from the paper. The dataset in the paper comprises 4 main figures and 11 figure supplements. Figure 4—figure supplement 1 is the only figure which has been found to be based on fabricated data. However, it contributed only minimally to the large body of data, addressing a minor mechanistic point. Moreover, Figure 4E also establishes the result previously shown in Figure 4—figure supplement 1. No other figures in the paper flowed from or were reliant on the result shown in the figure in question. Removal of Figure 4—figure supplement 1 has no effect on the study’s outcomes, as reflected in the title and abstract. This correction notice does not alter the validity of the overall scientific conclusions of this study. In addition, the key outcomes are supported by other work since published by other laboratories. No other authors were involved in the provision of the fabricated data. As such the removal of this data does not undermine the findings of the paper or the integrity of the other authors. Due to the removal of Figure 4—figure supplement 1 from this study, and according to the NHMRC and ICMJE guidelines defining the role of author and contributor, Professor Smyth’s name has been removed from the author list. Prof Smyth’s remaining contributions are now referred to in the acknowledgements section of the paper.
Errata / Notes
Corrects Article: ZDB-PUB-170201-13
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping