PUBLICATION
Embryonic exposures to chemicals acting on brain aromatase lead to different locomotor effects in zebrafish larvae
- Authors
- Blanc-Legendre, M., Sire, S., Christophe, A., Brion, F., Bégout, M.L., Cousin, X.
- ID
- ZDB-PUB-230716-38
- Date
- 2023
- Source
- Environmental Toxicology and Pharmacology 102: 104221 (Journal)
- Registered Authors
- Cousin, Xavier
- Keywords
- Bisphenol, cyp19a1b, endocrine disruption, larval photomotor response, neurotoxicity
- MeSH Terms
-
- Animals
- Aromatase/metabolism
- Benzhydryl Compounds/toxicity
- Brain
- Endocrine Disruptors*/metabolism
- Estrogens/pharmacology
- Larva/metabolism
- Zebrafish*/metabolism
- PubMed
- 37451529 Full text @ Environ. Toxicol. Pharmacol.
Citation
Blanc-Legendre, M., Sire, S., Christophe, A., Brion, F., Bégout, M.L., Cousin, X. (2023) Embryonic exposures to chemicals acting on brain aromatase lead to different locomotor effects in zebrafish larvae. Environmental Toxicology and Pharmacology. 102:104221.
Abstract
Pathways underlying neurodevelopmental effects of endocrine disruptors (EDs) remain poorly known. Expression of brain aromatase (aroB), responsible for estrogen production in the brain of teleosts, is regulated by estrogenic EDs and could play a role in their behavioral effects. We exposed zebrafish eleutheroembryos (0-120hours post-fertilization) to various concentrations of 16 estrogenic chemicals (incl. bisphenols and contraceptives), and of 2 aroB inhibitors. Behavior was monitored using a photomotor response test procedure. Both aroB inhibitors (clotrimazole and prochloraz) and a total of 6 estrogenic EDs induced significant behavioral alterations, including DM-BPA, BPC and BPS-MPE, three bisphenol substitutes which behavioral effects were, to our knowledge, previously unknown. However, no consensus was reported on the effects among tested substances. It appears that behavioral changes could not be linked to groups of substances defined by their specificity or potency to modulate aroB expression, or by their structure. Altogether, behavioral effects of estrogenic EDs in 120hours post-fertilization larvae appear unrelated to aroB but are nonetheless not to be neglected in the context of environmental safety.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping